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FORMULATION OF ETHOSOMAL GEL PREPARATION OF SEA GRAPE EXTRACT (Caulerpa racemosa (Forsskål) J. Agardh) EXTRACTED BY ULTRASONICATION AND PHYSICAL STABILITY TEST

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ABSTRACT

(A) ALI MUSTAFIKIN
(B) FORMULATION OF ETHOSOMAL GEL PREPARATION OF SEA GRAPE
EXTRACT (Caulerpa racemosa (Forsskål) J. Agardh) EXTRACTED BY
ULTRASONICATION AND PHYSICAL STABILITY TEST
(C) xvii + 149 pages; 29 tables: 22 figures; 38 appendices
(D) Keywords: sea grape extract, ultrasonication, ethoxa, antioxidant activity,
physical stability
(E) Sea grapes (Caulerpa racemosa) belong to the caulerpaceae family species of
the class Chlorophyceae can be used as antioxidants because they contain phenol
compounds, alkaloids, saponins, steroids, and flavonoids. The purpose of this
study was to formulate the ethosomal gel of sea grape extract and then determine
its antioxidant activity with the DPPH method and determine the best formula of
sea grape extract ethosome. Sea grapes were extracted by ultrasonication for 40
min then thickened and tested for antioxidant activity with the DPPH Method,
after which ethosomal nanovesicles were made, characterization tested and the
best formula was determined to be formulated into ethosomal gel preparations
of sea grape extract tested for physical and chemical stability. The results of the
study found the antioxidant activity of sea grape extract of 70.20 ± 0.13 bph.
The results of ethosome characterization show F3 is the best formula with a
polydispersity index of 0.392, particle size of 151.8 nm, zeta potential of -30.3
mV, and absorption efficiency of 97.83% ± 0.01. The test results of physical and
chemical quality parameters show good results and meet the requirements of gel
preparations. Physical stability test results and cycling test Ethoxal gel
preparations are physically stable, there is no phase separation and no
organoleptic changes. So it can be concluded that the ethosomal gel preparation
of sea grape extract ±(Caulerpa racemosa) has antioxidant activity that falls into
the range of strong and physically stable.
(F) Reference list: 34 (2000-2022)
(G) Prof. Dr. apt. Effionora Anwar, M.S
Dr. apt. Yesi Desmiaty, M.Si.
(H) 2023

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

TF 1641 23

Penerbit

Jakarta : Fakultas Farmasi Universitas Pancasila., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

2019210068

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Disolusi, Fukoidan, Tablet, Nanopartikel

Info Detail Spesifik

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Pernyataan Tanggungjawab

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